The neuronal NO synthase participation in the peripheral antinociception mechanism induced by several analgesic drugs
TRL Romero, LC Resende, IDG Duarte - Nitric Oxide, 2011 - Elsevier
The production of nitric oxide (NO) from l-arginine is catalyzed by NO synthase (NOS), which
exists as the following three isoforms: endothelial (eNOS), neuronal (nNOS), and inducible
(iNOS). The participation of this pathway in peripheral antinociception has been extensively
established by our group with the use of several types of drugs, including opioids,
cannabinoids, cholinergic, and α2C adrenoceptor agonists and nonsteroidal anti-
inflammatory drugs (NSAIDS), and even non-pharmacological procedures such as …
exists as the following three isoforms: endothelial (eNOS), neuronal (nNOS), and inducible
(iNOS). The participation of this pathway in peripheral antinociception has been extensively
established by our group with the use of several types of drugs, including opioids,
cannabinoids, cholinergic, and α2C adrenoceptor agonists and nonsteroidal anti-
inflammatory drugs (NSAIDS), and even non-pharmacological procedures such as …
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